Professor, Department of Biological Sciences
Year arrived at BSU: 2000
Department of Biology
Boise State University
Boise, ID 83725-1515
Office Location: Science Building, Room 228
Office Number: 208-426-2396
Lab Location:Science Building, Room 216
Troy Rohn graduated in 1990 from the University of California at Davis with a B.S. in Physiology. He received his Ph.D. in Pharmacology from the University of Washington , Seattle in 1994. His interests include the role of apoptosis in neurodegenerative diseases. Dr. Rohn had several Postdoctoral stints including two plus years living in Paris , France , one year at Montana State University in Bozeman , Montana , and two years at UC Irvine at the Institute of Brain Aging and Dementia under the direction of Dr. Carl Cotman. Dr. Rohn continues to collaborate extensively with UC Irvine and in addition with Dr. Eliezer Masliah at UC San Diego. He has obtained extramural funding continuously since his arrival at BSU including grants from NIH, AFAR and AHAF.
: This is a molecular neurobiology course for undergraduate and graduate-students. Topics covered are all aspects of neuronal function at the molecular level. A discussion of several neurodegenerative diseases including Parkinson’s, Alzheimer’s, and Schizophrenia are a few of diseases covered.
: This is a general pharmacology course for undergraduate and graduate-students. Topics include the pharmacokinetics and pharmacodynamics. All major drug classes are covered in this course.
- Both courses are taught in the fall semesters
: This is a non-majors course covering all aspects of biology. A two-hour weekly lab reinforces concepts taught in lecture. I also teach the electronic course for this class during spring semesters.
: A cell biology course that represents a core requirement for all biology majors. This course will be team taught with Dr. Cheryl Jorcyk starting in the spring semester of 2012.
The primary focus of my laboratory is involved in the research involving neurodegenerative diseases including to a large extent, Alzheimer’s disease (AD). During the progression of Alzheimer’s disease, many neurons die particularly in the area of the hippocampus. Because the hippocampus is an area of the brain involved in memory, AD is primary a disease where afflicted individuals lose their capacity for memory.
Currently, we are investigating whether caspase-cleavage of APOE4 underlies its pathogenesis in AD. The APOE4 allele, if inherited greatly increases the risk of AD, but how it contributes to disease progression is not known. We believe this protein may be susceptible to proteolytic cleavage by proteases and this inactivates the ability of this protein to function properly in the brain. This could contribute to disease progression by allowing for the accumulation of the toxic protein, beta-amyloid, that is normally removed from the brain, in part by functional APOE4. My lab has recently been awarded an NIH grant to investigate this hypothesis.
Our lab also has an interest in other neurodegenerative diseases including Parkinson’s, Pick’s, frontal temporal dementia and vascular dementia.
RECENT PUBLICATIONS (selected from 67 total)
Pollock, T.B., Mack, J.M., Day, R.J., Isho, N.F., Brown, R.J., Hayden, E.J. and Rohn T.T.
(2019). A fragment of apolipoprotein E4 leads to the downregulation of CXorf56, a novel ER-protein, and activation of BV2 microglial cells. In preparation
, Kim, N., Isho, N.F. and Mack, J.M. (2018). The potential of CRISPR/Cas9 gene editing as a treatment strategy for Alzheimer’s disease. J Alzheimers Dis Parkinsonism.
8(3). Pii: 439. Doi: 10.4172/2161-0460. Epub 2018 May 31.
Rohn, T.T. and Mack, J.M. (2018). Apolipoprotein E fragmentation within Lewy bodies of the human Parkinson’s disease brain. Int. J. Neurodegener Dis
Love, J.E., Day, R.J., Gause, J.W, Brown, R.J., Pu, X., Theis, D.I., Caraway, C.A., Poon, W.W., Rahman, A.A., Morrison, B.E., and Rohn T.T. (2017). Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer’s disease brain. Int J Physiol Pathophysiol Pharmacol: 9(2): 40-57
Gause J.W., Day, R.J., Caraway, C.A., Poon, W.W. and Rohn T.T. (2017). Evaluation of apolipoprotein E fragmentation as a biomarker for Alzheimer’s disease. J. of Neurology and Neurological Disorders
. 3(2): 204. DOI: 10.15744/2454- 4981.3.204
Rohn, T.T. and Moore, Z.D. (2017). Nuclear localization of apolipoprotein E4: A new trick for an old protein. Int. J. Neurol. Neurother.
4(2): DOI: 10.23937/2378-3001/1410067